Epitalon

Longevity Research only Human trials

Also called Epithalon, AEDG peptide

A four-amino-acid synthetic peptide developed in Russia from a pineal gland extract called epithalamin. It is studied for switching on telomerase, the enzyme that maintains chromosome ends, and for effects on melatonin release. Rodent studies reported longer lifespans.

Evidence at a glance

Evidence: Human trials — Studied in people
Status: Research compound only
Dosing: A dose has been tested in humans

Long-term human studies come from a single Russian group and have not been replicated independently.

What studies report

Longer lifespan and fewer tumours in mice and rats
Telomerase activation and telomere lengthening in human cell cultures
Restored melatonin rhythm in older monkeys and people in Russian studies

How it works

The synthetic tetrapeptide (Ala-Glu-Asp-Gly) matching the active sequence of the natural pineal complex. Reported to activate telomerase and restore melatonin rhythm.

Binds a receptor on the cell surface and signals inward

Where it acts

Acts body-wide rather than on one organ

The library groups this compound under Longevity. The diagram shows that target, not every tissue it reaches.

Illustrated

A chromosome pair close-up with structurally continuous capped ends, conceptual telomere research illustration.

AI-generated subject illustration; not a depiction of the compound or evidence of its effects.

Why people take it

Telomere length and longevityMelatonin and circadian rhythmAge-related declineSleep and melatonin rhythm

Reasons people seek it out — not a list of proven effects.

In practice Unapproved use

Taken as short pulsed courses, typically 10–20 days once or twice a year, rather than continuously
Treated in longevity circles as an annual 'reset' instead of a daily supplement
Frequently paired with the organ bioregulators

Science hasn't caught up: Pulsed annual dosing is near-universal practice, but it comes from the developer's protocols rather than from dose-finding studies.

Reported real-world use, not evidence and not a recommendation.

Dosing

What was tested Evidence

5–10 mg daily, in 10–20 day coursesRussian studies in older adults→ Reported melatonin rhythm restoration and, in long-term follow-up, lower mortality

What people report using Not evidence

10 mg daily for 10–20 days, once or twice a year
Treated as an annual reset rather than a daily supplement

Reported for reference, not as instruction. Nothing here is a recommendation to take anything, and most of these compounds are not approved for human use.

Status: Mostly animal and cell data, plus small Russian human studies. Not approved.

Route: Subcutaneous injection, or oral in the capsule bioregulator form; also sold as a ready-made intranasal spray
Sequence: Ala-Glu-Asp-Gly
Formula: C14H22N4O9
Molecular weight: 390.35 g/mol
CAS: 307297-39-8
Available as: 10 mg, 50 mg

View on PubChem →

Search PubMed for Epitalon → We link a live search rather than a fixed citation list, so it stays current and nothing here is a reference we have not checked.

Compared with

vs Endoluten (A-8 Pineal) →

Side-by-side pages for the compounds this one is most often confused with or taken alongside.

Educational information only. Nothing here is medical advice, a dosing protocol, or a recommendation to use any compound. Most entries describe substances not approved for human use. Talk to a licensed clinician before acting on anything you read here. How to read these entries.