Thymosin-β4 Fragment 1-4

Healing & repair Research only Animal studies

Also called Ac-SDKP, Seraspenide

The first four amino acids of thymosin-β4, which the body clips off naturally. This fragment carries much of the parent peptide's anti-inflammatory and anti-scarring activity. In animal models it reduced fibrosis in the heart, kidney and lung. ACE breaks it down, so ACE-inhibitor drugs raise its levels.

Evidence at a glance

Evidence: Animal studies — Not yet studied in people
Status: Research compound only
Dosing: No human study has set a dose

Animal only. It is broken down by ACE, so its levels are already altered by common blood pressure drugs.

What studies report

Reduced fibrosis in heart, kidney and lung models
Anti-inflammatory effects without the actin-binding activity of the full peptide

How it works

The first four residues of thymosin-β4, cleaved off naturally. This fragment blocks NF-κB activation and carries most of the parent peptide's anti-scarring and anti-inflammatory effect. ACE breaks it down, so ACE inhibitors raise its levels.

Binds a receptor on the cell surface and signals inward

Where it acts

Joints & cartilage

The library groups this compound under Healing & repair. The diagram shows that target, not every tissue it reaches.

Illustrated

A fibroblast with delicate processes nestled among parallel collagen fibres.

AI-generated subject illustration; not a depiction of the compound or evidence of its effects.

Why people take it

Fibrosis and scarringAnti-inflammatory use

Reasons people seek it out — not a list of proven effects.

Status: Animal and cell research only.

Route: Subcutaneous injection, from reconstituted lyophilised powder
Sequence: Ac-Ser-Asp-Lys-Pro
Formula: C20H33N5O9
Molecular weight: 487.5 g/mol
CAS: 127103-11-1
Available as: 10 mg

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Educational information only. Nothing here is medical advice, a dosing protocol, or a recommendation to use any compound. Most entries describe substances not approved for human use. Talk to a licensed clinician before acting on anything you read here. How to read these entries.