Kisspeptin-10

Hormonal Research only Human trials

Also called Kp-10, Metastin (45-54)

The shortest fully active fragment of kisspeptin, the brain signal that starts the reproductive hormone cascade. It triggers GnRH release, which in turn raises LH, FSH and sex hormones. It is studied in fertility treatment and low-testosterone states. The parent protein was first found as a suppressor of cancer spread.

Evidence at a glance

Evidence: Human trials — Studied in people
Status: Research compound only
Dosing: A dose has been tested in humans

Human studies are short single-dose experiments, not treatment courses.

What studies report

Triggers LH and testosterone release in healthy men
Used in fertility research to mature eggs with less risk of ovarian hyperstimulation
Increased brain responses to sexual and emotional cues in imaging studies

How it works

Acts upstream of the whole reproductive cascade: it triggers GnRH release from the hypothalamus, which in turn drives LH, FSH and the sex hormones. It is the switch that starts puberty.

Binds a receptor on the cell surface and signals inward

Where it acts

Pituitary gland

The library groups this compound under Hormonal. The diagram shows that target, not every tissue it reaches.

Illustrated

A midsagittal view of the human brain focusing on the hypothalamus and its anatomical relationship with the pituitary below. No pathway arrows or invented molecular structures.

AI-generated subject illustration; not a depiction of the compound or evidence of its effects.

Why people take it

Fertility and reproductive hormonesTestosterone supportLibido

Reasons people seek it out — not a list of proven effects.

In practice Unapproved use

Used in fertility and TRT-adjacent circles to support the body's own hormone signalling

Reported real-world use, not evidence and not a recommendation.

Dosing

What was tested Evidence

0.3–1 nmol/kg, intravenous bolus or infusionHuman reproductive endocrinology studies→ LH and testosterone release
Single bolus as an IVF triggerFertility trials→ Egg maturation with lower ovarian hyperstimulation risk

What people report using Not evidence

Short experimental use rather than ongoing courses

Reported for reference, not as instruction. Nothing here is a recommendation to take anything, and most of these compounds are not approved for human use.

Status: Used in human research studies. Not approved.

Route: Subcutaneous injection, from reconstituted lyophilised powder
Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Formula: C63H83N17O14
Molecular weight: 1302.4 g/mol
CAS: 374675-21-5
Available as: 3 mg

View on PubChem →

Search PubMed for Kisspeptin-10 → We link a live search rather than a fixed citation list, so it stays current and nothing here is a reference we have not checked.

Educational information only. Nothing here is medical advice, a dosing protocol, or a recommendation to use any compound. Most entries describe substances not approved for human use. Talk to a licensed clinician before acting on anything you read here. How to read these entries.