HMG

Hormonal Approved · US, EU & worldwide Human trials

Also called Human menopausal gonadotropin, Menotropins

A purified preparation of two pituitary hormones, FSH and LH, extracted from the urine of post-menopausal women. FSH drives sperm and egg maturation, LH drives sex hormone production, so the preparation supplies both signals at once.

Evidence at a glance

Evidence: Human trials — Studied in people
Status: An approved medicine in US, EU & worldwide
Dosing: No human study has set a dose

Approved and well evidenced for fertility. Its use for hormonal recovery after steroid or testosterone use is off-label and rests on very little published evidence. Because it is purified from pooled human urine, batch consistency and sourcing matter more than with a synthetic peptide.

What studies report

Stimulates follicle development and egg maturation in fertility treatment, in long-established human use
Restores sperm production in men with pituitary failure, in human studies
Supplies FSH activity that HCG alone does not

How it works

Delivers FSH and LH activity together. HCG covers the LH side only, so HMG is added when the FSH signal is also needed, which is the case for sperm maturation rather than just testosterone production.

Binds a receptor on the cell surface and signals inward

Where it acts

Pituitary gland

The library groups this compound under Hormonal. The diagram shows that target, not every tissue it reaches.

Illustrated

A histology-inspired close-up of normal endocrine cells surrounding a developing ovarian follicle, cellular view only.

AI-generated subject illustration; not a depiction of the compound or evidence of its effects.

Why people take it

Fertility treatmentSperm productionPost-cycle recoveryHormonal axis restart

Reasons people seek it out — not a list of proven effects.

In practice Off-label

Added to HCG in restart protocols on the view that FSH is needed for sperm recovery, not just testosterone
Far less commonly used than HCG, and considerably more expensive
Dosed in international units rather than milligrams, which trips people up

Science hasn't caught up: The fertility evidence is strong but the recovery protocols it is used in have essentially no trial support.

Reported real-world use, not evidence and not a recommendation.

Status: FDA-approved as a prescription fertility medicine. Used off-label for hormonal recovery.

Route: Subcutaneous or intramuscular injection
Sequence: Mixture of glycoprotein hormones with FSH and LH activity
Available as: 75 IU, 150 IU

Search PubMed for HMG → We link a live search rather than a fixed citation list, so it stays current and nothing here is a reference we have not checked.

Educational information only. Nothing here is medical advice, a dosing protocol, or a recommendation to use any compound. Most entries describe substances not approved for human use. Talk to a licensed clinician before acting on anything you read here. How to read these entries.