ARA-290
Nerve & pain In trials Human trials
Also called Cibinetide
An 11-amino-acid peptide modeled on one face of erythropoietin (EPO). It is built to trigger EPO's tissue-protective signaling without raising red blood cell counts. Most of the human work looks at small-fiber nerve damage and nerve pain in sarcoidosis and type 2 diabetes.
Evidence at a glance
- Evidence
- Human trials — Studied in people
- Status
- Reached clinical trials
- Dosing
- A dose has been tested in humans
Benefits came from phase 2 trials of a few hundred people; phase 3 confirmation is missing.
What studies report
- Reduced neuropathic pain scores in sarcoidosis and type 2 diabetes trials
- Regrowth of small nerve fibres in the cornea and skin
- No rise in red blood cell count, unlike EPO itself
How it works
Binds the innate repair receptor — a complex of the EPO receptor with CD131 — which carries erythropoietin's tissue-protective signalling. It deliberately misses the classic EPO receptor, which is why it protects nerves without raising red blood cell counts.
Where it acts
Acts on nerves, throughout the bodyThe library groups this compound under Nerve & pain. The diagram shows that target, not every tissue it reaches.
Illustrated
AI-generated subject illustration; not a depiction of the compound or evidence of its effects.
Why people take it
Reasons people seek it out — not a list of proven effects.
Dosing
What was tested Evidence
- 4 mg daily, subcutaneous28 daysPhase 2 in sarcoidosis with small-fibre neuropathy→ Reduced neuropathic pain; corneal nerve fibre regrowth
What people report using Not evidence
- 4 mg daily mirrors the trial
Reported for reference, not as instruction. Nothing here is a recommendation to take anything, and most of these compounds are not approved for human use.
Status: Phase 2 trials completed. Not approved.
- Route
- Subcutaneous injection, from reconstituted lyophilised powder
- Sequence
- pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser
- Formula
- C51H84N16O21
- Molecular weight
- 1257.3 g/mol
- CAS
- 1208243-50-8
- Available as
- 12 mg
Search PubMed for ARA-290 → We link a live search rather than a fixed citation list, so it stays current and nothing here is a reference we have not checked.
Educational information only. Nothing here is medical advice, a dosing protocol, or a recommendation to use any compound. Most entries describe substances not approved for human use. Talk to a licensed clinician before acting on anything you read here. How to read these entries.