5-Amino-1MQ
Metabolic Research only Animal studies
Also called 5-amino-1-methylquinolinium, NNMTi
Not a peptide — a small molecule that blocks NNMT, an enzyme fat cells use to burn through their nicotinamide supply. Blocking it raises cellular NAD+ and, in mice, made fat cells shed stored fat without any change in diet.
Evidence at a glance
- Evidence
- Animal studies — Not yet studied in people
- Status
- Research compound only
- Dosing
- No human study has set a dose
Mouse and cell-culture data only, and no human trial has been published. Oral bioavailability in people is unestablished.
What studies report
- Reduced fat mass in diet-induced obese mice while food intake stayed the same
- Higher NAD+ and SAM levels in cultured fat cells
- Promoted muscle stem cell proliferation in culture
How it works
Blocks NNMT, the enzyme fat cells use to consume nicotinamide. With that drain closed, cellular NAD+ and SAM rise, which is the proposed route to increased fat metabolism.
Where it acts
PancreasThe library groups this compound under Metabolic. The diagram shows that target, not every tissue it reaches.
Illustrated
AI-generated subject illustration; not a depiction of the compound or evidence of its effects.
Why people take it
Reasons people seek it out — not a list of proven effects.
In practice Unapproved use
- Taken orally in capsules, usually in 4–8 week blocks
- Marketed and used for fat loss without appetite suppression
- Often stacked with MOTS-c and NAD+ precursors
Science hasn't caught up: Sold widely as an oral fat-loss supplement on the strength of mouse data alone.
Reported real-world use, not evidence and not a recommendation.
Dosing
No human study has established a dose for this compound.
What people report using Not evidence
- 50–150 mg daily, oral, in 4–8 week blocks
Mouse data only. No human trial has established any dose.
Reported for reference, not as instruction. Nothing here is a recommendation to take anything, and most of these compounds are not approved for human use.
Status: Research compound. Not approved.
- Route
- Oral capsule — a small molecule, so digestion is not a barrier; also sold as a ready-made intranasal spray
- Formula
- C10H11IN2
- Molecular weight
- 286.11 g/mol
- CAS
- 42464-96-0
- Available as
- 10 mg
Search PubMed for 5-Amino-1MQ → We link a live search rather than a fixed citation list, so it stays current and nothing here is a reference we have not checked.
Compared with
Side-by-side pages for the compounds this one is most often confused with or taken alongside.
Educational information only. Nothing here is medical advice, a dosing protocol, or a recommendation to use any compound. Most entries describe substances not approved for human use. Talk to a licensed clinician before acting on anything you read here. How to read these entries.