Sermorelin
Growth hormone Approved · US (withdrawn) Human trials
Also called GRF (1-29), Geref
The first 29 amino acids of growth-hormone-releasing hormone, the shortest piece that keeps full activity. It prompts the pituitary to make and release its own growth hormone, so the body's normal feedback controls stay in place. It has a short half-life of minutes.
Evidence at a glance
- Evidence
- Human trials — Studied in people
- Status
- An approved medicine in US (withdrawn)
- Dosing
- A dose has been tested in humans
The branded drug was discontinued for commercial reasons, not safety. Effects are modest compared with growth hormone itself.
What studies report
- Stimulates the body's own growth hormone with normal feedback intact
- Used diagnostically to test pituitary function
- Older studies reported improved sleep and body composition in adults
How it works
The shortest fragment of growth-hormone-releasing hormone that keeps full activity. It acts on the pituitary GHRH receptor, so the body's own feedback control over growth hormone stays intact.
Where it acts
Pituitary glandThe library groups this compound under Growth hormone. The diagram shows that target, not every tissue it reaches.
Illustrated
AI-generated subject illustration; not a depiction of the compound or evidence of its effects.
Why people take it
Reasons people seek it out — not a list of proven effects.
In practice Off-label
- The growth hormone peptide most often prescribed through anti-aging and wellness clinics
- Taken nightly, which suits its very short half-life
Reported real-world use, not evidence and not a recommendation.
Dosing
What was tested Evidence
- 1 mcg/kg, intravenousPituitary function testing→ GH release used diagnostically
- 0.2–0.3 mg nightly, subcutaneousChildhood growth hormone deficiency (former approved use)→ Improved growth velocity
What people report using Not evidence
- Prescribed nightly through anti-aging clinics, which suits its very short half-life
Reported for reference, not as instruction. Nothing here is a recommendation to take anything, and most of these compounds are not approved for human use.
Status: Formerly FDA-approved (Geref) for childhood growth hormone deficiency; the brand was discontinued for commercial reasons.
- Route
- Subcutaneous injection, from reconstituted lyophilised powder
- Sequence
- Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
- Formula
- C149H246N44O42S
- Molecular weight
- 3357.9 g/mol
- CAS
- 86168-78-7
- Available as
- 5 mg
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Educational information only. Nothing here is medical advice, a dosing protocol, or a recommendation to use any compound. Most entries describe substances not approved for human use. Talk to a licensed clinician before acting on anything you read here. How to read these entries.