FOXO4-DRI

Longevity Research only Animal studies

Also called FOX-04, Proxofim

A synthetic peptide built from mirror-image amino acids in reverse order, which makes it resistant to breakdown. It blocks the FOXO4 protein from holding on to p53 inside senescent ('worn-out') cells, which pushes those cells to self-destruct. In aged mice this improved fur, kidney function and activity.

Evidence at a glance

Evidence: Animal studies — Not yet studied in people
Status: Research compound only
Dosing: No human study has set a dose

A single landmark 2017 mouse study plus follow-ups. Nothing in humans.

What studies report

Cleared senescent cells in aged mice
Restored fur density, kidney function and running capacity in old mice

How it works

Built from mirror-image amino acids in reverse order so enzymes cannot cut it. It blocks FOXO4 from holding p53 in the nucleus of senescent cells; released, p53 triggers the self-destruct those worn-out cells have been avoiding.

Binds a receptor on the cell surface and signals inward

Where it acts

Acts body-wide rather than on one organ

The library groups this compound under Longevity. The diagram shows that target, not every tissue it reaches.

Illustrated

A conceptual senescent mammalian cell cutaway with an enlarged nucleus and textured membrane.

AI-generated subject illustration; not a depiction of the compound or evidence of its effects.

Why people take it

Senescent cell clearanceLongevity and tissue rejuvenation

Reasons people seek it out — not a list of proven effects.

In practice Unapproved use

Used in senolytic experimentation, typically as short infrequent courses

Science hasn't caught up: A handful of self-experimenters are using a compound whose entire evidence base is one mouse study.

Reported real-world use, not evidence and not a recommendation.

Status: Animal and cell research only.

Route: Subcutaneous injection, from reconstituted lyophilised powder
Available as: 2 mg

Search PubMed for FOXO4-DRI → We link a live search rather than a fixed citation list, so it stays current and nothing here is a reference we have not checked.

Educational information only. Nothing here is medical advice, a dosing protocol, or a recommendation to use any compound. Most entries describe substances not approved for human use. Talk to a licensed clinician before acting on anything you read here. How to read these entries.