Dihexa
Cognitive & neuro Research only Animal studies
Also called PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
A modified three-amino-acid peptide derived from angiotensin IV, reworked so it resists breakdown and crosses into the brain. It amplifies hepatocyte growth factor signalling through the c-Met receptor, which drives the formation of new connections between neurons.
Evidence at a glance
- Evidence
- Animal studies — Not yet studied in people
- Status
- Research compound only
- Dosing
- No human study has set a dose
Rodent and cell data from a small number of labs, with no human trials. Because it drives growth-factor signalling, the theoretical cancer risk has not been ruled out in long-term studies.
What studies report
- Reversed learning deficits in a rat model of Alzheimer's disease
- Promoted new dendritic spines and synapses in cultured neurons
- Described in papers as far more potent than BDNF at forming synapses
How it works
Amplifies hepatocyte growth factor signalling through its receptor c-Met, which drives the formation of new dendritic spines and synapses. The hexanoyl and aminohexanoic caps make it resist breakdown and cross into the brain.
Where it acts
BrainThe library groups this compound under Cognitive & neuro. The diagram shows that target, not every tissue it reaches.
Illustrated
AI-generated subject illustration; not a depiction of the compound or evidence of its effects.
Why people take it
Reasons people seek it out — not a list of proven effects.
In practice Unapproved use
- Used in very small amounts by the nootropic community
- More cautious users avoid it over the theoretical cancer risk from growth-factor signalling
Science hasn't caught up: Circulating in nootropic use with no human trials and an unresolved growth-signalling concern.
Reported real-world use, not evidence and not a recommendation.
Dosing
No human study has established a dose for this compound.
What people report using Not evidence
- Very small amounts, measured in micrograms, taken orally or applied topically
No human trials. Because it amplifies growth-factor signalling, the long-term risk is genuinely unknown.
Reported for reference, not as instruction. Nothing here is a recommendation to take anything, and most of these compounds are not approved for human use.
Status: Research compound. Not approved.
- Route
- Oral or injection; reported to cross the blood-brain barrier
- Sequence
- Hexanoyl-Tyr-Ile-Ahx-NH2
- Formula
- C27H44N4O5
- Molecular weight
- 504.7 g/mol
- CAS
- 1401708-83-5
- Available as
- 10 mg
Search PubMed for Dihexa → We link a live search rather than a fixed citation list, so it stays current and nothing here is a reference we have not checked.
Educational information only. Nothing here is medical advice, a dosing protocol, or a recommendation to use any compound. Most entries describe substances not approved for human use. Talk to a licensed clinician before acting on anything you read here. How to read these entries.